解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only mixed effects on childhood diarrhea. Arriving at the inception of the United Nations' Sustainable De...
journal_title:BMC medicine
pub_type: 共识发展会议,杂志文章
doi:10.1186/s12916-019-1410-x
更新日期:2019-08-28 00:00:00
abstract:BACKGROUND:The objectives of this study were to understand the differences in mortality rate, risk factors for mortality, and cause of death distribution in three neonatal age sub-groups (0-2, 3-7, and 8-27 days) and assess the change in mortality rate with previous assessments to inform programmatic decision-making in...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1372-z
更新日期:2019-07-19 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis and progression of NAFLD is complex with many unanswered questions. We conducted genome-w...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1364-z
更新日期:2019-07-17 00:00:00
abstract:BACKGROUND:Monogenic diabetes (MgD) accounts for 1-2% of all diabetes cases. In adults, MgD is difficult to distinguish from common diabetes causes. We assessed the diagnosis rate and genetic spectrum of MgD using next-generation sequencing in patients with late adolescence/adult-onset diabetes referred for a clinical ...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1363-0
更新日期:2019-07-11 00:00:00
abstract:BACKGROUND:Tobacco smoking is a leading cause of cardiovascular disease (CVD) morbidity and mortality. Evidence on the relation of smoking to different subtypes of CVD, across fatal and non-fatal outcomes, is limited. METHODS:A prospective study of 188,167 CVD- and cancer-free individuals aged ≥ 45 years from the Aust...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1351-4
更新日期:2019-07-03 00:00:00
abstract:BACKGROUND:Abnormal BMI is associated with discouraging IVF outcomes in fresh autologous or oocyte donor cycles, whether or not such a relation also holds true for women undergoing frozen-thawed embryo transfer (FET) remains unknown. In addition, it remains unclear the detrimental effect of abnormal BMI on IVF outcomes...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1354-1
更新日期:2019-06-26 00:00:00
abstract:BACKGROUND:Several accomplishments have been achieved in triple-negative breast cancer (TNBC) research over the last year. The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer into the immunotherapy era. Nevertheless, despite encouraging result...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-019-1326-5
更新日期:2019-05-09 00:00:00
abstract:BACKGROUND:Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease remains questioned. MAIN BODY:Accumulating evidence from clinical trial...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-019-1323-8
更新日期:2019-05-08 00:00:00
abstract:BACKGROUND:It is critically important to conduct research on stigmatized conditions, to include marginalized groups that experience stigma, and to develop interventions to reduce stigma. However, such research is ethically challenging. Though superficial reference is frequently made to these widely acknowledged challen...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1317-6
更新日期:2019-04-29 00:00:00
abstract:BACKGROUND:Brazil's Estratégia Saúde da Família (ESF) is one of the largest and most robustly evaluated primary healthcare programmes of the world, but it could be affected by fiscal austerity measures and by the possible end of the Mais Médicos programme (MMP)-a major intervention to increase primary care doctors in u...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1316-7
更新日期:2019-04-26 00:00:00
abstract:BACKGROUND:Health-related research funders, regulators and journals expect that de-identified individual-level health data be shared widely, with as few restrictions as possible; yet, in reality, the volume of shared data remains low. MAIN BODY:Health researchers and other data producers are reluctant to share their d...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1315-8
更新日期:2019-04-17 00:00:00
abstract:BACKGROUND:Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected PaC difficult. This large international population-based study aimed at exploring factors associated with survival in patients with resected TNM stage I-II PaC r...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1304-y
更新日期:2019-03-25 00:00:00
abstract:BACKGROUND:Managing hearing communication for residents living with hearing loss and dementia in long-term care settings is challenging. This paper explores how care can be effective in optimising hearing communication for residents living with dementia. We argue that the underlying notion of permission or authorisatio...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1286-9
更新日期:2019-03-04 00:00:00
abstract:BACKGROUND:Guidelines recommend that clinicians should make brief opportunistic behavioural interventions to patients who are obese to increase the uptake of effective weight loss programmes. The objective was to assess the effect of this policy on socioeconomic equity. METHODS:One thousand eight hundred eighty-two co...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-019-1284-y
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Thymic size in early infancy predicts subsequent survival in low-income settings. The human thymus develops from early gestation, is most active in early life and is highly sensitive to malnutrition. Our objective was to test whether thymic size in infancy could be increased by maternal and/or infant nutriti...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-019-1264-2
更新日期:2019-02-18 00:00:00
abstract:BACKGROUND:Interventions to alleviate stigma are demonstrating effectiveness across a range of conditions, though few move beyond the pilot phase, especially in low- and middle-income countries (LMICs). Implementation science offers tools to study complex interventions, understand barriers to implementation, and genera...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1237-x
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis. METHODS:We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotla...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1252-6
更新日期:2019-01-31 00:00:00
abstract:BACKGROUND:A sizeable fraction of tuberculosis (TB) cases go undiagnosed. By analysing data from enhanced demographic, microbiological and geospatial surveillance of TB registrations, we aimed to identify modifiable predictors of inequitable access to diagnosis and care. METHODS:Governmental community health workers (...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-019-1260-6
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND:Risk stratification and management of acute myocardial infarction patients continue to be challenging despite considerable efforts made in the last decades by many clinicians and researchers. The aim of this study was to investigate the metabolomic fingerprint of acute myocardial infarction using nuclear mag...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1240-2
更新日期:2019-01-07 00:00:00
abstract::The original article [1] contained an error in the presentation of Figure 1; this error has now been rectified and Figure 1 is now presented correctly. ...
journal_title:BMC medicine
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12916-018-1232-2
更新日期:2018-12-28 00:00:00
abstract:BACKGROUND:Recent global progress in scaling up malaria control interventions has revived the goal of complete elimination in many countries. Decreasing transmission intensity generally leads to increasingly patchy spatial patterns of malaria transmission in elimination settings, with control programs having to accurat...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1181-9
更新日期:2018-10-18 00:00:00
abstract:BACKGROUND:The focus of this study is to identify particular microRNA (miRNA) signatures in exosomes derived from plasma of 435 human epidermal growth factor receptor 2 (HER2)-positive and triple-negative (TN) subtypes of breast cancer (BC). METHODS:First, miRNA expression profiles were determined in exosomes derived ...
journal_title:BMC medicine
pub_type: 杂志文章,多中心研究
doi:10.1186/s12916-018-1163-y
更新日期:2018-10-10 00:00:00
abstract:BACKGROUND:The UK, like a number of other countries, has a refugee resettlement programme. External factors, such as higher prevalence of infectious diseases in the country of origin and circumstances of travel, are likely to increase the infectious disease risk of refugees, but published data is scarce. The Internatio...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1125-4
更新日期:2018-08-28 00:00:00
abstract:BACKGROUND:In an era when obesity prevalence is high throughout much of the world, there is a correspondingly pervasive and strong culture of weight stigma. For example, representative studies show that some forms of weight discrimination are more prevalent even than discrimination based on race or ethnicity. DISCUSSI...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1116-5
更新日期:2018-08-15 00:00:00
abstract:BACKGROUND:Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected from neighborhoods surrounding a prison in Lima, Peru, where inmates experience a high risk of M...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1111-x
更新日期:2018-08-03 00:00:00
abstract:BACKGROUND:Caregivers may promote the uptake of science into patient care and the practice of evidence-informed medicine. The purpose of this study was to determine whether caregiver-mediated (non-clinical caregiver-delivered) interventions are effective in improving patient, caregiver, provider, or health system outco...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-018-1097-4
更新日期:2018-07-12 00:00:00
abstract:BACKGROUND:Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. METHODS:An open-label, non-inferiority, 1:1 randomized trial was conducted at three academic hospitals in So...
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-018-1093-8
更新日期:2018-07-10 00:00:00
abstract::Malaria at international borders presents particular challenges with regards to elimination. International borders share common malaria ecologies, yet neighboring countries are often at different stages of the control-to-elimination pathway. Herein, we present a case study on malaria, and its control, at the border be...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1081-z
更新日期:2018-06-26 00:00:00
abstract:BACKGROUND:Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable outcomes. Optimising care for polypharmacy necessitates effective targeting and monitoring of interventions. This requires a valid, reliable measure of ...
journal_title:BMC medicine
pub_type: 杂志文章,评审
doi:10.1186/s12916-018-1078-7
更新日期:2018-06-13 00:00:00
abstract:BACKGROUND:Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary art...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1065-z
更新日期:2018-05-17 00:00:00
abstract:BACKGROUND:Little is known about the impact of growing migration on the pattern of tuberculosis (TB) transmission in middle-income countries. We estimated TB recent transmission and its associated factors and investigated the presence of cross-transmission between South American migrants and Brazilians. METHODS:We stu...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1055-1
更新日期:2018-04-30 00:00:00
abstract:BACKGROUND:Marine resources including fatty fish are important sources of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), which are important for brain development. To our knowledge, this is the first randomized controlled trial (RCT) investigating the impact of fatty fish on cognition in preschool children....
journal_title:BMC medicine
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12916-018-1020-z
更新日期:2018-03-12 00:00:00
abstract:BACKGROUND:Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of survival in critically ill adults, but little data exist for African children living in malaria-endemic...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1014-x
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease (COPD). Our aim was to externally validate and concurrently compare prognostic scores for 3-year...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1013-y
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth the adrenals are essential for neonate salt retention through secretion of aldosterone, while adequate glucocorticoids are required to prevent adrenal in...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-018-1009-7
更新日期:2018-02-12 00:00:00
abstract:BACKGROUND:Populations exposed to humanitarian emergencies are particularly vulnerable to mental health problems, including new onset, relapse and deterioration of psychotic disorders. Inadequate care for this group may lead to human rights abuses and even premature death. The WHO Mental Health Gap Action Programme Int...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0960-z
更新日期:2017-12-11 00:00:00
abstract:BACKGROUND:Depression in tuberculosis increases the risk for adverse health outcomes. However, little is known about comorbid depression and tuberculosis in the general population. Thus, we assessed the association between depression and tuberculosis, and the decrements in health status associated with this comorbidity...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0975-5
更新日期:2017-11-28 00:00:00
abstract:BACKGROUND:Dietary assessment is complex, and strategies to select the most appropriate dietary assessment tool (DAT) in epidemiological research are needed. The DIETary Assessment Tool NETwork (DIET@NET) aimed to establish expert consensus on Best Practice Guidelines (BPGs) for dietary assessment using self-report. M...
journal_title:BMC medicine
pub_type: 杂志文章,实务指引
doi:10.1186/s12916-017-0962-x
更新日期:2017-11-15 00:00:00
abstract:BACKGROUND:Obesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM). Women with polycystic ovary syndrome (PCOS) are commonly obese, which aggravates the severity of PCOS clinical expression. Relationships between these common insul...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0957-7
更新日期:2017-11-06 00:00:00
abstract:BACKGROUND:The use of early morning sputum samples (EMS) to diagnose tuberculosis (TB) can result in treatment delay given the need for the patient to return to the clinic with the EMS, increasing the chance of patients being lost during their diagnostic workup. However, there is little evidence to support the superior...
journal_title:BMC medicine
pub_type: 杂志文章
doi:10.1186/s12916-017-0947-9
更新日期:2017-10-27 00:00:00